American Association of Veterinary Immunologists (AAVI) & AAI Veterinary Immunology Committee Joint Symposium: Vaccination: The Balance between Immunity and Pathogenesis
Laurel J. Gershwin, University of California, Davis
Laura C. Miller, National Animal Disease Center, ARS, USDA
Linda J. Saif, Ohio Agricultural Research and Development Center, The Ohio State University, Gut reactions to probiotics, commensals, and antibiotics influence immunity to rotavirus in neonates
Jeffrey L. Stott, University of California, Davis, School of Veterinary Medicine, Controlling epizootic bovine abortion (foothill abortion): development and application of a live virulent vaccine
Julia F. Ridpath, National Animal Disease Center, ARS, USDA, BVDV vaccines: the yin and yang of immunosuppression versus immune response
Shafiqul I. Chowdhury, LSU School of Veterinary Medicine, Targeting immunosuppressive and virulence genes for genetically engineered BHV-1 vaccine: walking a fine line between reduced pathogenicity and protective immune response
Drawing from both human and veterinary research, this year’s symposium will focus on the challenge in viral vaccine design of attenuating virulence while retaining protective immunogenicity. Research highly relevant to infant immunization will cite the use of probiotics to enhance vaccine responses to human rotavirus in a germ-free piglet model. The story of “foothill abortion” in western states cattle will be used to illustrate the ways that understanding the unique pathogenesis of a pathogen can ultimately lead to a successful vaccine. Finally, researchers studying pestiviruses and bovine herpes viruses will share how understanding protective immunity and viral pathogenesis is critical for development of effective vaccines.